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Fig. 6. The serial effects of {alpha}-CTx MII, {alpha}-CTx AuIB and Mec are additive and not the result of gradual deterioration of the preparation. (A) Actual optical traces, spatially averaged over the entire ganglion from the experiment in Fig. 5, are shown instead of bars to highlight the progression of the drug effects. Here, all the trials recorded during the experiment are shown. Note the obvious clustering of responses according to colour. (B) Inhibitory effects on evoked synaptic responses (spatially averaged over the whole ganglion) of sequential application of nAChR-antagonists. (C) Examples of differential sensitivity of individual neurones to these antagonists. As in Fig. 5, all traces were band-pass filtered between 6.6 and 200 Hz.





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