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Fig. 2. Phylogenetic relationship of amino acid sequences for the NtpB domain from invertebrate, mammalian brain-type (B2), mammalian kidney-type (B1) and yeast V-ATPase B-subunit isoforms. GenBank accession numbers are listed here in descending order with respect to the cladogram, beginning with A. aegypti (AAD27666 XP_312029, P31410, P31401, AAP37188 AAF08281 CAA44721 P31408, P50517, NP_476561, NP_001683, P31407, NP_598918, XP_232119, P16140, P31411). Scale represents the proportion of amino acid difference between sequences. Bootstrap values from 1000 replicates are listed at each node. Sequences are placed into two groups, specific and generalist, based on the highlighted bootstrap values and general functional repertoire of the inclusive isoforms. Percent amino acid identity with the A. franciscana NtpB domain is recorded in parentheses after each species name.





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