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Fig. 6. Cardioprotective effect of SNAP (100 µmol l–1) on the
hypoxia-induced damage incurred by isolated myocytes in vitro. Figs 6
and 7 show the percent change
in the total fraction of stained cells after 60 min hypoxia in the presence of
various agents, compared to that recorded after hypoxia alone. Under hypoxic
conditions, SNAP reduced the percentage of stained cells. In contrast,
L-NAME, which blocks hypoxia-induced synthesis of NO, increased the
percentage of stained cells when given alone, and eliminated the
cardioprotective influence of SNAP when the two drugs were administered
simultaneously.
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