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Fig. 4. Effects of presumed KATP activators on the percentage change in ventricular action potential duration (APD) under normoxic conditions. APD90 was shortened by 10, 30 and 60 min exposure to SNAP (100 µmol l–1), a nitric oxide (NO) donor (N=4), and by 10 min exposure to 8-Br-cGMP (200 µmol l–1), a stable cGMP analog (N=6). Diazoxide (50 µmol l–1), a specific mitochondrial KATP (mitoKATP) channel opener, did not significantly affect APD (N=6). Values shown are mean changes ± 1 S.E.M.





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