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Fig. 7. Worms adapt to the loss of nicotinic MC stimulation by altering resting
potential to preserve pharyngeal pumping. (A) Sample intracellular voltage
recordings from wild-type worms show that resting potential is about -73 mV.
(B) Resting potential in cca-1 single mutants matches that of
wild-type worms. (C) In contrast, a recording from an eat-2 mutant
reveals that resting potential is elevated by 
13 mV over wild-type
resting potential, and has a slight tendency to rise between action
potentials. (D) A recording from an eat-2; cca-1 double mutant
reveals an elevated resting potential that drifts significantly towards
positive potentials between action potentials. (E) Average resting membrane
potential for above four strains. Mean ±
S.E.M.; N=12 (WT), 10
(cca-1), 15 (eat-2), 11 (eat-2; cca-1).
*Significantly different from both the wild type and cca-1
(P<0.005, t-test).
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