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Fig. 5. CCA-1 activity is crucial for the efficient initiation of action potentials
in animals with defects in cholinergic neurotransmission. (A) EPGs from
unc-17(e245); cca-1(ad1650) double mutants contain many I-phase
spikes, reflecting the fact that MC is often unsuccessful in triggering a
pharyngeal muscle action potential. The frequency of I-phase spikes is far
greater in an unc-17(e245); cca-1(ad1650) double mutant than in an
unc-17(e245) single mutant (shown in
Fig. 3D). (B) EPGs from
snt-1(md290); cca-1(ad1650) mutant worms contain rare action
potentials separated by many clusters of I-phase spikes. Again, the rate of
failure of action potential generation is far greater in a snt-1(md290);
cca-1(ad1650) double mutant than in a snt-1(md290) single mutant
(shown in Fig. 3D). EPSPs are
marked with large arrows. E-phase spikes are marked with small arrows. I-phase
spikes are marked with arrowheads.
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