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Fig. 3. Effect of presynaptic inhibition on Ca entry and transmitter release. (A)
The relationship between Ca entry (observed as a change in fluorescence),
during stimulation of the excitor alone (black) or the excitor and inhibitor
(grey). Presynaptic inhibition caused a significant reduction in the
fluorescence transient (average 20±1%) in excitor terminals (paired
t-test, P<0.001, 122 terminals from 12 animals). (B) An
example of excitatory junction potentials (EJPs) recorded from a muscle fibre
when stimulating only the excitor (black) or the excitor and inhibitor
together (grey). (C) Pooled data shows that, on average, the first, second and
third EJPs were inhibited by 42±4%, 51±4% and 59±2%,
respectively (N=27 cells from 18 animals). (D) Facilitation of EJPs
resulting from stimulation of the excitor alone (black) or the excitor with
the inhibitor (grey) was calculated by dividing the amplitude of the second
and third EJP by the amplitude of the first. There was significantly less
facilitation of the third EJP with inhibition (paired t-test,
P<0.01, N=27 cells from 18 preparations).
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