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Fig. 7. Quantitative summary of effects of guanylate cyclase and phosphodiesterase
inhibitors [ODQ (1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one) and zaprinast,
respectively] on peristalsis (A) and their representative effects on the
behaviour of whole colonies (B,C). (A) Histogram showing the actions of ODQ
and zaprinast on peristalsis, as well as their interactions with the effects
of other signalling molecules (see Results). Statistical significance:
P>0.05 (n.s.), *P<0.05 or
**P<0.01 with the paired t-test. N=6
(ODQ/SNAP), 4 (melatonin/ODQ) and 5 (zaprinast/db cGMP/IBMX). (B) Injection of
ODQ in the left half of the colony led to a slightly contracted state and
stronger peristalsis (as illustrated by the marginal fold) relative to the
control (right) half. (C) Injection of aminoguanidine in the left half of
another colony led to a relaxed and quiescent state relative to the control
half where robust peristalsis occurs (compare the two pictures of the same
colony photographed 30 s apart). Black line indicates the position of the
axial canal.
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