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Fig. 2. Recordings of effects of NO (nitric oxide) donors on peristaltic
contractions of reduced preparations of R. koellikeri. (A) Recording
of a single preparation immersed in 40 ml of ASW and first exposed to 40 ml of
solvent (ASW), then consecutively to 40 and 400 µl of 1 mmol l-1
SIN-1 (amino-3-morpholinyl-1,2,3-oxadiazolium) chloride to obtain final bath
concentrations of 1 and 10 µmol l-1, respectively. Note the
diversity of shape of traces reflecting the contribution of different
contraction waves to peristaltic events. Note also the dose-dependent increase
in contraction amplitudes and in wave synchrony after exposure to SIN-1 and
the reversibility of this response after washing. (B) Effect of SNAP
(S-nitroso-N-acetylpenicillamine) on contractions induced by field
electrical stimulation. Stimulation trains of 6 monopolar pulses of 10 ms each
at 5 V and 2 Hz were applied as shown at arrows. Note that the induced robust
contractions were invariably followed by a sharp, transient drop of the
ongoing peristaltic waves. Note also the reversible drop in amplitude and
duration of the induced contraction in the presence of SNAP. µN,
microNewton.
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