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Fig. 1. Schematic diagram of the model. Six body compartments (rectangular boxes) interconnected by blood circulation (bold solid lines), with arterial and venous mixing compartments and circulatory lags (ta, th, tc and tv). Compartmental blood flows are coupled to compartmental metabolic rate and oxygen delivery (local vascular regulation) and to respiratory drive (systemic vascular regulation). Fine solid arrows indicate internal and external gas exchange. Dotted arrows indicate neural respiratory drives. See text for a detailed description. Abbreviations are listed in Tables 1 and 2.





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