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Fig. 7. The effects of bathing saline salicylate concentration on (A) fluid secretion rate, (B) secreted fluid salicylate concentration and (C) salicylate flux. Each point is the mean ±S.E.M. for 6-12 tubules. The inset in B shows the relationship between bathing saline salicylate concentration (mmol l-1) and S/M, the ratio of salicylate concentration in the secreted fluid to that in the bathing medium. Curves in B and C were fitted to the Michaelis-Menten equation using nonlinear regression analysis. Jmax refers top the maximum rate of transport and Kt to the concentration of salicylate required to produce 50% of the maximum flux.





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