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Fig. 2. The {gamma}MR cell. With this configuration of transport elements, both Na+ and Cl– can be absorbed from ambient NaCl, and Cl– can be taken up from Na+-free solution. As pictured, it lacks a basolateral mechanism for eliminating HCO3– and hence would be unable to absorb Na+ from Cl–-free media. Whether this is, in fact, the case remains to be determined. The apical Cl– channel is not shown, since it would be closed in FW.





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