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Fig. 3. Effect of the calmodulin inhibitor calmidazolium on ciliary beat frequency
(CBF) in unidentified ciliary cells in culture. Application of 100 mmol
l1 5-hydroxytryptamine (5-HT) produced a significant
increase in CBF versus the saline control (asterisk:
P<0.05, N=7 cells). Application of either 0.1% DMSO
(N=7 cells) or 2 mmol l1 calmidazolium (Cal;
N=12 cells) caused no change in CBF. When 2 mmol l1
Cal was co-applied with 100 mmol l1 5-HT, the calmodulin
inhibitor blocked the stimulatory effect of 5-HT (N=9 cells).