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Fig. 6. Effect of ISO on the relationship between SR Ca2+ uptake and the
[Ca2+]i. (A) Representative intracellular
Ca2+ recordings in control and with 1 µmol l1
isoproterenol (ISO). Bars above traces indicate membrane potential (top bar)
and extracellular solution (lower bar); , regular bath solution; +,
bath solution with 10 mmol l1 caffeine. (B) Effect of
membrane potential on the average Ca2+ transient during
depolarization (black bars) and the peak Ca2+ transient elicited by
10 mmol l1 Caf (white bars, N=7). (C) Effect of ISO
on the relationship between SR Ca2+ uptake rate and
[Ca2+]i (N=7). Solid (control) and dotted (ISO)
lines represent fits of data with a Hill equation.