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Fig. 3. Relationship between SR Ca2+ loading and membrane potential. The Caf releasable SR Ca2+ content was plotted as a function of the membrane potential Vm of the preceding depolarization in the absence (CON; filled symbols) or the presence of 1 µmol l–1 isoproterenol (ISO; open symbols). Data (N=6) were fit with a Boltzmann equation. Arrows indicate the K0.5 without (solid) and with ISO (broken line).





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