|
| |
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 9. Tension recordings from the intestinal vein showing the vasodilatory effect
of the calcium ionophore, A23187 (A), and its effect in the presence of the
cyclo-oxygenase inhibitor, indomethacin (B), and in the absence of an intact
endothelium (C). Vessels were pre-incubated with indomethacin
(10–5 mol l–1) for approximately 10 min
prior to being constricted with endothelin-1 (ET-1; 10–8 mol
l–1), and at the point of maximal vasoconstriction, the
ionophore (3x10–6 mol l–1) was added.
Pre-incubation with indomethacin or disruption of the endothelium abolished
the dilation induced by the addition of the ionophore
(3x10–6 mol l–1; N=3).
|
