|
| |
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 8. Tension recordings from the dorsal aorta showing the vasodilatory effect of
nicotine (A) and its effect in the presence of the cyclo-oxygenase inhibitor,
indomethacin (B). Vessels were preincubated with indomethacin
(10–5 mol l–1) for approximately 10 min
prior to being pre-constricted with endothelin-1 (ET-1; 10–8
mol l–1). At the point of maximal vasoconstriction, nicotine
(3x10–4 mol l–1) was administered. (C)
Mean response (% vasodilation) of nicotine on pre-constricted dorsal aorta and
intestinal vein in the absence of (filled bars) and in the presence of
indomethacin (open bars). Note that there is no significant difference in the
nicotine-mediated dilation (dorsal aorta, P=0.63; intestinal vein,
P=0.20; N=5).
|
