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Fig. 7. Tension recordings from the dorsal aorta showing the vasodilatory effect of
nicotine (A), and its effect in the presence of the specific nNOS inhibitor
N
-propyl-L-arginine (PLA) (B). Vessels
were pre-incubated with PLA (10–5 mol l–1)
for approximately 10 min prior to being pre-constricted with endothelin-1
(ET-1; 10–8 mol l–1). At the point of
maximal vasoconstriction, nicotine (3x10–4 mol
l–1) was added. Note that the vasodilation is reduced in the
presence of PLA. (C) Mean response (% vasodilation) of nicotine on
pre-constricted dorsal aorta and intestinal vein in the in the presence of
(filled bars) and in the absence of PLA (open bars). Note that PLA
significantly reduced the nicotine-mediated dilation (dorsal aorta and
intestinal vein, P<0.05; *denotes significant difference;
N=5).
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