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Fig. 2. Dopamine inhibits the expression of fictive swimming. Robust swimming was
induced by a combination of a 30 min bath application of the amine mixture (50
µmol l–1 serotonin and 50 µmol l–1
octopamine) administered to the brain and nerve cord, followed by a 30 min
saline `washout' (Mesce et al.,
2001). At the end of washout, 50 µmol l–1 DA
was applied to the brain and nerve cord for 30 min, thus terminating the
expression of fictive swimming. The entire last 9 min of washout (labeled min
1, to arrow) and first 6 min of DA application (min 10 to end of record) are
depicted here. Black boxes depict entire swim episodes, defined as a series of
uninterrupted swim motor neuron (DE-3) bursts in the dorsal posterior (DP)
nerve. Swim inhibition by DA occurred within 1 min, and swimming was never
observed in any preparations treated with DA (N=5).
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