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Fig. 1. Effects of 20 min of severe hypoxia (0.3 mg l–1), indicated by the bar on x-axis. (A) Heart rate (fH), (B) ventral aortic blood pressure (PVA), (C) dorsal aortic blood pressure (PDA) in control (•, N=14) aminophylline-treated ({blacktriangledown}, N=7), atropine-treated ({blacksquare}, N=7) and tubocurarine-treated ({diamondsuit}, N=7) sharks. All values are means ± S.E.M. Time-dependent changes were tested using repeated measures ANOVA with Dunnet post-test. Lines indicate the time periods that differ significantly from the last normoxic value (P<0.05). Differences in the effects of hypoxia between aminophylline-treated and control sharks (A) and between hypoxia- and atropine-treated (D) are indicated by an asterisk.





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