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Fig. 7. Effect of serotonin (5HT) on the spontaneous beating rate of in
vitro atrial cultured cells. Vertical: percent of the maximum effect.
Horizontal: serotonin corresponding to a final concentration ranging from of
10–11 to 10–7 mol l–1. A
significant increase (P<0.05) was observed at concentrations of
5HT equal or higher than 10–9 mol l–1.
Values obtained with concentrations equal or higher than 10–6
mol l–1 are not plotted because the beatings became erratic,
and the cells were detaching themselves from the plastic bottom of the Petri
dishes, showing a toxic effect at such concentrations.
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