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Fig. 2. Effect of the IP3R blockers, TMB-8 and 2-APB, on the response of shark VSM to the ETBR agonist IRL 1620 in Ca2+-free Ringer. (A) Representative tracings of the response of VSM to ETBR agonist stimulation in the presence or absence of TMB-8 or 2-APB. (B) Both inhibitors block the [Ca2+]i mobilization response by about 70% (*P<0.01).





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