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Fig. 1. Intracellular Ca2+ ([Ca2+]i) responses of shark VSM to ETBR receptor agonists and endothelin-1 (ET-1). (A) The ETBR agonists IRL 1620 and sarafotoxin S6c (SRX) produce the same increase in [Ca2+]i as ET-1. (B) Representative tracing of the cytosolic calcium responses of shark anterior mesenteric artery VSM. The ETBR agonist IRL 1620 causes a prompt increase in [Ca2+]i. In the continued presence of IRL 1620, addition of ET-1 does not cause any further significant peak increase in [Ca2+]i.





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