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Fig. 2. HIF-1{alpha} localization in brain under physiological and pathophysiological conditions. (A) Heterogeneity of nuclear HIF-1{alpha} localization in neurons of the mouse cortex under physiological conditions is probably related to the heterogeneous distribution of tissue PO2. In addition, HIF-{alpha} expression may be influenced by other factors discussed, such as PHD activity or growth factor signaling. (B) In contrast, human brain tumors show distinct nuclear HIF-1{alpha} localization in pallisading cells close to the necrotic core (N) of glioblastoma multiforme.





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