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Fig. 7. Scheme of the proposed relationship between VEGF and Ang-2 in controlling capillary density. The constitutive Ang-1, produced in pericytes and neighboring cells, normally maintains mechanical stability of the capillary through interaction with the Tie-2 receptor. Upregulated Ang-2, occurring during changes in oxygen availability, binds to the Tie-2 receptor without phosphorylation/activation, blocking Ang-1, releasing the pericyte and destabilizing the capillary. During hypoxic exposure, in the presence of VEGF, there is endothelial cell proliferation and angiogenesis. But, during reoxygenation after hypoxic adaptation in the absence of VEGF there is apoptosis and vessel regression. (Drawn by P. Pichiule, based on the hypothesis presented by Holash et al., 1999.)





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