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Fig. 6. Effects of specific receptor antagonists on maximum contractile force
developed by steroid-treated ventricle strips from both male (A) and female
(B) rainbow trout at 0.5 Hz. Strips were pretreated for 10 min with flutamide
(Flut; 0.1 mmol l–1), mifepristone (Mif; 0.1 mmol
l–1) or tamoxifen (Tam; 0.25 mmol l–1) to
inhibit androgen, cortisol and estradiol receptors, respectively. Flut, Mif
and Tam had no independent effects on contractile force in males or females.
Steroid concentrations used were: 0.3 µmol l–1
11-ketotestosterone (11KT), 0.3 µmol l–1 testosterone (T),
0.1 µmol l–1 cortisol (C) in males, 0.01 µmol
l–1 C in females, and 1 nmol l–1 estradiol
(E2) in females. In males, Flut blocked the inotropic effects of androgens
(11KT and T) but not C. Mif blocked the effects of C in males and females but
not 11KT and T in males and E2 in females. In females, Tam prevented the
positive effects of E2 and C. All values are means +
S.E.M. (N=7–10).
*P<0.05 versus EtOH control strips.
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