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Fig. 2. Amino acid alignment of vertebrate arginase genes. Strictly conserved residues are boxed, bolded and darkly shaded while residues that maintain the physio-chemical properties of a position are boxed and lightly shaded. A previous comparison of 21 arginase enzymes in both eukaryotes and prokaryotes (Perozich et al., 1998) identified residues that are strictly conserved, highly conserved (at least 80% conserved) and display invariant similarity (i.e. D/E, S/T or V/I/L/M). These positions are indicated beneath the alignment by *, # and ^, respectively. Three periods (...) indicate incomplete or missing sequence information. The sequences are identified with a four-letter code based on their species name and followed by either their unique GenBank accession number or a unique gene indicator, i.e. ARG01. Species included are Oncorhynchus mykiss (Onmy), Danio rerio (Dare), Takifugu rubripes (Taru), Rana catesbeiana (Raca), Xenopus laevis (Xela), Rattus norvegicus (Rano), Mus musculus (Mumu), Sus scrofa (Susc) and Homo sapiens (Hosa).





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