Fig. 8. Organization and structure of the putative eth gene from Anopheles gambiae. (A) The promoter region contains the putative ecdysone receptor response element (EcRE) followed by the eth open reading frame, interrupted by an intron. The signal peptide (open box) is followed by ETH1 and ETH2 (hatched boxes), separated by GRR-processing sites for dibasic cleavage and amidation. (B) The non-coding nucleotide sequence of Anopheles eth is shown in lower-case letters. The upstream putative pulindromic EcRE (aggtcaattcacct) is bold and underlined, the intron donor and acceptor motifs are underlined and in bold and italic, and the poly-A signal is underlined. Predicted nucleotide sequence of an open reading frame and deduced amino acid sequence are indicated by upper-case letters. Putative active peptides ETH1 and ETH2 are boxed, and amidation and processing signals (GRR) are underlined.

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