Fig. 2. T-cell responses as measured by -interferon ELISPOT to pools of peptides from the ME-TRAP malaria insert seven days after various DNA and/or MVA vaccination regimes. Summed net responses to pools of peptides from all of the vaccine insert, from the T9/96 strain of TRAP encoded in the vaccine and from TRAP from another P. falciparum strain, 3D7, are shown. The arithmetic mean of the responses for the subjects in that group are presented with an error bar to indicate the standard error of the mean. D, DNA-ME TRAP given by intramuscular injection into the deltoid muscle; G, DNA-ME TRAP given epidermally by needleless delivery device; M, MVA-ME TRAP given by intradermal injection. The numerals included in parentheses in the regimen names correspond to the dosage of vaccine, in mg for DNA and p.f.u.x10⁷ for MVA. For example, the last column DDDMM(15) shows summed ELISPOT responses for subjects vaccinated with three priming doses of 2 mg DNA-ME TRAP i.m. followed by two boosting doses of MVA-ME TRAP at 1.5x10⁸ p.f.u.

Return to article