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Fig. 6. (A) Serotonin (1 µmoll-1), gramine (100 µmoll-1) and octopamine (100 µmoll-1) do not affect the action potential duration of eat-18; avr-15 mutants (P>0.5). (B) Serotonin (1 µmoll-1) significantly decreases the action potential duration of avr-15 mutants (P<0.001). This effect is blocked by addition of 100 µmoll-1 gramine (P<0.05), but not by 100 µmoll-1 octopamine (P>0.5). (C) Serotonin (1 µmoll-1), gramine (100 µmoll-1) and octopamine (100 µmoll-1) do not affect the action potential duration of eat-2; avr-15 mutants (P>0.5). (D) Gramine (100 µmoll-1) and octopamine (100 µmoll-1) suppress the M3 activity (P<0.001) and increase the action potential duration of wild-type worms (P<0.05).





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