Fig. 3. The S. domuncula retinoid X receptor (RXR). The deduced RXR from S. domuncula, RXR_SUBDO, was aligned with other most similar sequences from human, retinoid X receptor gamma (RXRg_HUMAN; accession number NP_008848), C. elegans, hormone receptor/zinc finger protein (HR-ZF_CAEEL; NP_491103) and D. melanogaster, hepatocyte nuclear factor 4 (HNF-4_DROME; S36218), as well as the partial sequence from a coral (Acropora millepora), the nuclear receptor AmNR8 (AMNR8_ACRMI; AAL29201). Residues conserved (similar or related with respect to their similar physico-chemical properties) in all sequences are shown in white on black and those occurring in at least three sequences in black on gray. The characteristic DNA-binding domain, the two zinc finger modules (#++#) with the conserved cysteine residues (C), are marked. The DNA-binding domain is provided with the conserved residues of the P-box as well as of the D-box (marked). In addition, the borders of the putative secondary structures within the ligand-binding site, the ten -helices (H) and the ß-turn, have been adopted from Giguère (1999). The nuclear receptor signature (NRS) and the activator function-2 (AF2) are indicated.

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