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Fig. 1. The biosynthesis of hepoxilin A3 and its hydrolysis to trioxilin A3 from arachidonic acid, as reported by Pace-Asciak et al. (1983) in mammalian cells. 12-HPETE, 12-hydroperoxy-5,8,10,13-eicosatetraenoic acid; hepoxilin A3, 8-hydroxy-11,12-epoxy-5,9,14-eicosatrienoic acid; trioxilin A3, 8,11,12-trihydroxy-5,9,14-eicosatrienoic acid.





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