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Fig. 4. LY294002 inhibits mitochondrial accumulation at sites of nerve growth factor (NGF) stimulation. LY294002 treatment prevented the accumulation of mitochondria in the region of NGF stimulation (N=12; paired t-test). Dimethylsulfoxide (DMSO; vehicle) alone did not affect the mitochondrial response to NGF stimulation. The density of mitochondria is 3-fold higher in the 10 µm region of the axon adjacent to the NGF-coated bead than in similar proximal and distal non-bead control regions (N=9; paired t-test). * represents statistical significance at P<=0.001.





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