Fig. 10. The effects of the potent inhibitor of agonist-induced phospholipase C (PLC) activity, U-73122 (U7P), and its weaker analog, U-73343 (U7W) on odorant-evoked responses. (A,C) Representative electro-olfactogram (EOG) recordings to a mixture of 100 µmol l^–1 L-amino acids (AA; alanine, arginine, glutamate and methionine), polyamines (PA; 10 µmol l^–1 putrescine and cadaverine and 2 µmol l^–1 spermine) and 10 µmol l^–1 bile salts (BS; sodium taurocholate and taurolithocholate) prior to (i), during (ii) and after (iii) adaptation to 1 µmol l^–1 U-73122 (U7P) and 1 µmol l^–1 U-73343 (U7W), respectively. DS, dimethyl sulfoxide; C, CFTW control. The EOG response to ATP has been offset to allow for comparison. (B,D) Percentage of unadapted response (mean ± S.D.) to the adapting controls (underlined), (U7P in B; U7W in D), L-amino acids, polyamines, bile salts and ATP during adaptation to U7P (in B) and U7W (in D). Data in B and D were compiled from three fish. The adapting solution is underlined. X, Y and Z designate statistical significance across groups (one-way ANOVA; Tukey's post hoc test, P<0.05).

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