Fig. 5. The blockade of the Na+ current by Cn11 is not voltage-dependent. Current/voltage relationships were obtained under control conditions (open circles) and 3 min after the application of 1 µmol l–1 (filled squares) or 3 µmol l–1 (open squares) Cn11. The inward currents were elicited by depolarizing from a holding potential of –60 mV to +50 mV, in increments of 10 mV, with pulses of 10 ms duration. Currents start at approximately –40 mV and reach a maximum value of approximately 0 mV. I/Im, normalized Na+ current.
