Fig. 4. (A) Effects of 1 µmol l^–1 ionomycin alone on short-circuit current (I_sc) and tissue conductance (G_t). When post-treated with 0.1 mmol l^–1 IBMX + 0.5 mmol l^–1 db-cAMP, G_t and I_sc increased markedly. (B) Effects of 1 µmol l^–1 ionomycin alone and subsequent addition of 0.1 mmol l^–1 IBMX + 0.5 mmol l^–1 db-cAMP on unidirectional Cl^– fluxes (J_sm, serosal-to-mucosal flux; J_ms, mucosal-to-serosal flux) and net Cl^– secretion (J_net). Hr1, hour 1; Hr2, hour 2. Values are means ± S.E.M. Other details as in Fig. 2.

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