Fig. 1. The Drosophila melanogaster CRF-like gene. (A) cDNA and deduced peptide sequence of Dh. Putative dibasic convertase cleavage sites are underlined. The C-terminal amidation signal glycine residue is in italic. The positions of introns in the genomic sequence are marked with ><. The predicted peptide is indicated in blue. The encoded peptide has a signal peptide, with a predicted cleavage site between amino acid residues 24 and 25, marked with ^, as predicted by PSORTII Prediction program (http://psort.nibb.ac.jp/form2.html). The polyadenylation signal is indicated in yellow. Differences between the genomic sequence and the cDNA are marked in red. (B) Genomic context of Dh. View of region 85E of chromosome 3R. The neighbours of Dh are, on the negative strand, Scm, an RNA polymerase II transcription factor implicated in gene silencing, and CG9492, a dynein ATPase implicated in microtubule-based movement. Within an intron of Dh, on the opposite strand, is frost (fst), a gene implicated in response to cold. Dh (old) denotes the original, incomplete, Gadfly annotation of the Dh gene.

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