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Fig. 8. Schematic representation of amino acid ligand-gating of cationic channel conductance in CAATCH1 (Tyr147) and the Y147F (Phe147) mutant. (A) Endogenous WT currents in the absence of ligands. (B) No Y147F current in the absence of ligands. (C) Increased WT currents gated by extracellular L-proline. (D) No Y147F current gated by extracellular L-proline. (E) WT Na+ inward current blocked by extracellular L-methionine. (F) Y147F currents enhanced by extracellular L-methionine.





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