Fig. 1. CAATCH1 (TC 2.A.22.2.4 transporter superfamily classification), Na⁺:neurotransmitter transporter family members (SNF; TC 2.A.22) all possess a conserved tyrosine residue (filled circles). (A) Location of Tyr¹⁴⁷ in the third transmembrane domain of CAATCH1. The predicted secondary structure is adapted from Feldman et al. (2000). (B) Alignment of third transmembrane domain residues of CAATCH1 with some representative members of the SNF family showing a universally conserved tyrosine residue representing Tyr¹⁴⁷ in CAATCH1 (http://ca.expasy.org/cgi-bin/blast.pl?sequence=Q9U5A9 ).

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