Fig. 1. Evolutionary tree of uncoupling proteins (UCPs) and other mitochondrial carriers. The unrooted evolutionary tree represents inferred genetic distances (the numerical values indicate the number of base substitutions that change the amino acid sequences) between UCP sequences obtained from GeneBank (Protpars program from PHYLIP package) (Felsenstein, 1988). Abbreviations, species and accession numbers are as follows: HuUCP1 is Homo sapiens (human) UCP1, P25874; OcUCP1 is Oryctolagus cuniculus (rabbit) UCP1, P14271; RnUCP1 is Rattus norvegicus (rat) UCP1, P04633; HmUCP is Eupetomena macroura (hummingbird) UCP, AF255729; SsUCP2 is Sus scrofa (pig) UCP2, AAD05201; MmUCP2 is Mus musculus (mouse) UCP2, P70406; CcUCP2 is Cyprinus carpio (carp) UCP2, CAB46248; DrUCP2 is Danio rerio (zebrafish) UCP2, CAB46268; BtUCP3 is Bos taurus (cow) UCP3, AAC61762; HuUCP3 is H. sapiens (human) UCP3, P55916; StUCP is Solanum tuberosum (potato) UCP, CAA72107; AtUCP is Arabidopsis thaliana (thale cress) UCP, CAA77109; BtMPCP is B. taurus (cow) mitochondrial carrier protein, P12234; MmBMCP1 is M. musculus (mouse) brain mitochondrial carrier protein, AAD03674; CeSMCF is Caenorhabditis elegans (worm) similar mitochondrial carrier family, AAB54239; HuUCP4 is H. sapiens (human) UCP4, AAD16995; HuADP/ATP1 is H. sapiens (human) ADP/ATP translocator, P12235; RnADP/ATP1 is R. norgevicus (rat) ADP/ATP carrier, Q05962. Reproduced from Vianna et al. (2001) with permission from the American Physiological Society.

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