Fig. 4. The motor patterns induced by muscarinic agonists and by nitric oxide are independent. (A) The generation of the motor pattern induced by the NO donor hydroxylamine (left) does not involve muscarinic signalling since it is not blocked by the muscarinic antagonist atropine. (B) The generation of the motor pattern induced by the NO donor sodium nitroprusside (SNP) does not involve muscarinic signalling, since it is not blocked by the muscarinic antagonist scopolamine. (C) The generation of the motor pattern induced by the muscarinic agonist pilocarpine does not involve NO signalling, since it is not blocked by the soluble guanylyl cyclase (sGC) inhibitor 1H-(1,2,4)oxa-diazolo(4,3a)-quinoxalin-1-one (ODQ). (D) The generation of the motor pattern induced by the muscarinic agonist oxotremorine does not involve NO signalling, since it is not blocked by the sGC inhibitor ODQ. cl mn, closer motor nerve; op mn, opener motor nerve; DMSO, dimethylsulphoxide.
