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Fig. 3. Radial phylogenetic tree depicting the evolutionary relationship of Fundulus heteroclitus 14-3-3.a to the seven known mammalian and some Xenopus laevis 14-3-3 isoforms. 14-3-3 proteins from different vertebrates (labeled with species name) that are of the same isoform-type (either {alpha}, ß, {gamma}, {epsilon}, {eta}, {sigma}, or {tau}) cluster together (gray background). Such clusters are labeled with the isoform-type of the corresponding 14-3-3 proteins in each cluster. F. heteroclitus 14-3-3.a (boxed in red) may be evolutionarily distinct from the 14-3-3 isoforms that are known from higher vertebrates or be a homolog of 14-3-3{zeta} or 14-3-3ß.





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