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First published online March 12, 2009
Journal of Experimental Biology 212, 986-993 (2009)
Published by The Company of Biologists 2009
doi: 10.1242/jeb.021808
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T3 and the thyroid hormone β-receptor agonist GC-1 differentially affect metabolic capacity and oxidative damage in rat tissues

P. Venditti1,*, G. Chiellini2, A. Bari1, L. Di Stefano1, R. Zucchi2, A. Columbano3, T. S. Scanlan4 and S. Di Meo1

1 Dipartimento delle Scienze Biologiche, Sezione di Fisiologia, Università di Napoli, 80134 Napoli, Italy
2 Dipartimento di Scienze dell'Uomo e dell'Ambiente (G.C.), University of Pisa, Pisa 56126, Italy
3 Department of Toxicology, Oncology, and Molecular Pathology Unit, University of Cagliari, 09124 Cagliari, Italy
4 Department of Physiology and Pharmacology and Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, OR 97239, USA


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  		Fig. 1. Effect of T3 or GC-1 treatment of hypothyroid rats on cytochrome oxidase (COX) activity in tissue homogenates. Values are means ± s.e.m. of eight different experiments. COX activity is expressed in µmol O min–1 g–1 tissue. C, control euthyroid rats; H, hypothyroid rats; H+T3, hypothyroid T3-treated rats; H-GC-1, hypothyroid GC-1-treated rats. aSignificant vs C rats; bsignificant vs H rats; csignificant vs H+T3 rats. The level of significance was chosen as P<0.05.

 

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  		Fig. 2. Effect of treatment with T3 or GC-1 of hypothyroid rats in response to in vitro oxidative challenge of tissue homogenates. Tissue susceptibility to stress was evaluated by determining the variation, with concentration of homogenate, of light emission from a luminescence reaction. Emission values are given as percentages of an arbitrary standard (44 ng ml–1 peroxidase). The curves were computed from experimental data by the equation E=aC/exp(bC) (see Results for details). C, control euthyroid rats; H, hypothyroid rats; H+T3, hypothyroid T3-treated rats; H+GC-1, hypothyroid GC-1-treated rats.

 

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© The Company of Biologists Ltd 2009