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First published online March 12, 2009
Journal of Experimental Biology 212, 954-960 (2009)
Published by The Company of Biologists 2009
doi: 10.1242/jeb.025171
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Nitric oxide increases myocardial efficiency in the hypoxia-tolerant turtle Trachemys scripta

Mikkel Misfeldt, Angela Fago and Hans Gesser*

Department of Biological Sciences, Building 1131, University of Aarhus, DK-8000, Aarhus C, Denmark


Figure 1
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  		Fig. 1. Representative traces showing three consecutive 40 min recordings of twitch force (upper panel) and O2 consumption (lower panel). (1 mmHg= 0.133 kPa.)

 

Figure 2
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  		Fig. 2. (A) O2 consumption (µmol O2 min–1 g–1). (B) Developed twitch force (mN). (C) Ratio of twitch force to O2 consumption recorded before (black bars) and after (gray bars) the addition of 0.1 mmol l–1 L-arginine (L-Arg) in full oxygenation (N=6). Data are means ± s.e.m. *Significant change from the initial value (P<0.05).

 

Figure 3
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  		Fig. 3. (A) O2 consumption (µmol O2min–1 g–1). (B) Developed twitch force (mN). (C) Ratio of twitch force to O2 consumption recorded for preparations sequentially subjected to no addition, 0.1 mmol l–1 L-arginine (L-Arg) and L-Arg+1 mmol l–1 asymmetric dimethylarginine (ADMA) (N=6), as indicated. As control (D–F) the three parameters were also recorded according to the same time schedule in preparations receiving neither L-Arg nor ADMA (N=5). Data are means ± s.e.m. *Significant change from the initial value (P<0.05).

 

Figure 4
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  		Fig. 4. (A) O2 consumption (µmol O2 min–1 g–1). (B) Developed twitch force (mN) recorded for preparations sequentially subjected to no addition, 1 mmol l–1 asymmetric dimethylarginine (ADMA) and 1 mmol l–1 ADMA+0.1 mmol l–1 L-arginine (L-Arg), as indicated (N=5).

 

Figure 5
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  		Fig. 5. Results for four ventricular samples treated with DAF-2 DA as described in Table 1. (A, sample 1) Tissue autofluoroscence in the presence of L-arginine (L-Arg) (0.1 mmol l–1) and absence of 4,5-diaminofluorescein diacetate (DAF-2 DA). (B, sample 2) Basal nitric oxide (NO) production without L-Arg added. (C, sample 3) NO production with 0.1 mmol l–1 L-Arg. (D, sample 4) Effect of asymmetric dimethylarginine (ADMA) (1 mmol l–1) in the presence of 0.1 mmol l–1 L-Arg.

 

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