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First published online December 26, 2008
Journal of Experimental Biology 212, 238-248 (2009)
Published by The Company of Biologists 2009
doi: 10.1242/jeb.025296
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Glycogen storage and muscle glucose transporters (GLUT-4) of mice selectively bred for high voluntary wheel running

Fernando R. Gomes1,*, Enrico L. Rezende1, Jessica L. Malisch1, Sun K. Lee1, Donato A. Rivas2, Scott A. Kelly1, Christian Lytle3, Ben B. Yaspelkis, III2 and Theodore Garland, Jr1,{dagger}

1 Department of Biology, University of California, Riverside, CA 92521, USA
2 Exercise Biochemistry Laboratory, Department of Kinesiology, California State University Northridge, Northridge, CA 911330-8287, USA
3 Division of Biomedical Sciences, University of California, Riverside, CA 92521, USA


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  		Fig. 1. GLUT-4 abundance in gastrocnemius muscle was much higher in the selectively bred `high runner' (HR) lines of mice than in non-selected control (C) lines after five days of wheel access (Group 1, as outlined in Table 1). Clearly, this differential was not a simple linear function of the amount of wheel running performed by individual mice on the previous night (Table 2, P=0.9573 for effect of wheel revolutions). As discussed in the text, this seems to represent a case of increased `self-induced adaptive plasticity' in the HR lines of mice (Swallow et al., 2005Go; Garland and Kelly, 2006Go). A representative western blot for GLUT-4 from six individuals is also shown.

 

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  		Fig. 2. Liver glycogen concentration showed a significant (P=0.0040) negative relation with amount of wheel revolutions in the 02:00 h group (Group 2, as outlined in Table 1; see Table 2 for statistical analysis), but no differences among control (C), `high runner' (HR) normal (`selected') or HR mini-muscle mice.

 

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