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First published online May 1, 2009
Journal of Experimental Biology 212, 1423-1428 (2009)
Published by The Company of Biologists 2009
doi: 10.1242/jeb.000729
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What is the function of neuroglobin?

Thorsten Burmester1,* and Thomas Hankeln2

1 Institute of Zoology and Zoological Museum, University of Hamburg, Martin-Luther-King-Platz 3, D-20146 Hamburg, Germany
2 Institute of Molecular Genetics, Johannes Gutenberg University of Mainz, J. J. Becherweg 30a, D-55099 Mainz, Germany


Figure 1
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  		Fig. 1. Phylogenetic history of vertebrate globins. The simplified tree has been combined from different sources (Burmester et al., 2002Go; Burmester et al., 2000Go; Kugelstadt et al., 2004Go; Roesner et al., 2005Go). Globins with clear respiratory function (i.e. Mb and Hb) are shaded in grey. Note that haemoglobins from Agnatha and Gnathostomata (haemoglobin {alpha} and β) are not monophyletic.

 

Figure 2
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  		Fig. 2. Some postulated functions of neuroglobin. Neuroglobin may support the supply of O2 to the electron transport chain in mitochondria (A), may detoxify reactive oxygen or nitrogen species (B), may convert NO to NO3– at high PO2 and NO2– to NO at low PO2 (C), act as a signal protein by inhibiting the dissociation of GDP from G{alpha} (D) or prevent hypoxia-induced apoptosis via reduction of cytochrome c (E).

 

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