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First published online April 20, 2007
Journal of Experimental Biology 210, 1607-1612 (2007)
Published by The Company of Biologists 2007
doi: 10.1242/jeb.004887
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Common aging pathways in worms, flies, mice and humans

Stuart K. Kim

Department of Developmental Biology and Genetics, Stanford University Medical Center, Stanford, CA 94305-5329, USA


Figure 1
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  		Fig. 1. The electron transport chain decreases expression with age in humans, mice, flies and worms. Rows represent either human tissues or model organisms. Columns correspond to 95 genes in the electron transport chain gene set. Scale represents the normalized slope of the change in log2 expression level with age. Grey indicates that genes were not present in that species. Original data from Zahn et al. (Zahn et al., 2006Go).

 

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  		Fig. 2. Animals in natural populations die of predation and disease, not old age.

 

Figure 3
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  		Fig. 3. Three categories of aging predicted by the mutation accumulation theory.

 

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© The Company of Biologists Ltd 2007