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First published online August 31, 2007
Journal of Experimental Biology 210, 3301-3310 (2007)
Published by The Company of Biologists 2007
doi: 10.1242/jeb.006106

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Ventilatory and cardiovascular actions of centrally administered trout tachykinins in the unanesthetized trout

Jean-Claude Le Mével^1,*, Frédéric Lancien¹, Nagi Mimassi¹ and J. Michael Conlon²

¹ Laboratoire de Traitement de l'Information Médicale, INSERM U650, and Laboratoire de Neurophysiologie, Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale, 22 avenue Camille Desmoulins, CS 93837, 29238 Brest Cedex 3, France
² Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates

View larger version (50K): [in this window] [in a new window]   Fig. 1. Recording traces in a single unanesthetized trout, illustrating the changes observed in ventilatory movements (ventilation), dorsal aortic blood pressure (PDA) and electrocardiographic (ECG) signals 15 min after intracerebroventricular (ICV) injection of (A) 0.5 µl vehicle and (B) 50 pmol NP. Note that, compared with ICV injection of vehicle, the injection of NP produces an increase in ventilation rate but a potent reduction in ventilation amplitude.

View larger version (58K): [in this window] [in a new window]   Fig. 2. Time course of the effects of intracerebroventricular injection of (1) 0.5 µl vehicle (open bars, N=16), (2) 25 pmol NP (horizontal-hatched bars, N=8), (3) 50 pmol NP (cross-hatched bars, N=9) and (4) 100 pmol NP (gray bars, N=8) on (A) fV, (B) VAMP, (C) VTOT, (D) mean PDA, and (E) fH in unanesthetized trout. The arrow indicates when the injection was given. *P<0.05 vs vehicle at corresponding post-injection period and vs pre-injection value.

View larger version (36K): [in this window] [in a new window]   Fig. 3. Time course of the effects of intra-arterial injection of (1) 50 µl vehicle (open bars, N=16), (2) 50 pmol NP (cross-hatched bars, N=8), and (3) 250 pmol NP (filled bars, N=8) on (A) fV, (B) VAMP, (C) VTOT, (D) mean PDA and (E) fH, in unanesthetized trout. The arrow indicates when the injection was given. *P<0.05 vs vehicle at corresponding post-injection period and vs pre-injection value.

View larger version (52K): [in this window] [in a new window]   Fig. 4. Time course of the effects of intracerebroventricular injection of (1) 0.5 µl vehicle (open bars, N=16), (2) 50 pmol SP (cross-hatched bars, N=8), (3) 100 pmol SP (gray bars, N=10) and (4) 250 pmol SP (filled bars, N=10) on (A) fV, (B) VAMP, (C) VTOT, (D) mean PDA and (E) fH, in unanesthetized trout. The arrow indicates when the injection was given. *P<0.05 vs vehicle at corresponding post-injection period and vs pre-injection value.

View larger version (58K): [in this window] [in a new window]   Fig. 5. Time course of the effects of intracerebroventricular injection of (1) 0.5 µl of vehicle (open bars, N=16), (2) 50 pmol NKA (cross-hatched bars, N=7), (3) 100 pmol NKA (gray bars, N=8), and (4) 250 pmol NKA (filled bars, N=7) on (a) fV, (B) VAMP, (C) VTOT, (D) mean PDA and (E) fH, in unanesthetized trout. The arrow indicates when the injection was given. *P<0.05 vs vehicle at corresponding post-injection period and vs pre-injection value.