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First published online February 15, 2006
Journal of Experimental Biology 209, 817-825 (2006)
Published by The Company of Biologists 2006
doi: 10.1242/jeb.02045
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Differential effects of experimental and cold-induced hyperthyroidism on factors inducing rat liver oxidative damage

P. Venditti1,*, R. Pamplona2, V. Ayala2, R. De Rosa1, G. Caldarone1 and S. Di Meo1

1 Dipartimento delle Scienze Biologiche, Sezione di Fisiologia, Università di Napoli, I-80134 Napoli, Italy
2 Departament de Ciènces Mèdiques Bàsiques, Universitat de Lleida, 25198 Lleida, Spain


Figure 1
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  		Fig. 1. Serum levels of free triodothyronine (FT3) and thyroxine (FT4) in control (C), cold-exposed (CE), and T3-treated (HT3) or T3-treated (HT4) rats. Values are means ± s.e.m. of eight different experiments. *Significant vs C rats; {dagger}significant vs CE rats; {ddagger}significant vs HT3 rats. The level of significance was chosen as P<0.05.

 

Figure 2
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  		Fig. 2. Effect of cold exposure and hormonal [triodothyronine (T3) or thyroxine (T4)] treatment on oxygen consumption of liver homogenate. Values are means ± s.e.m. of eight different experiments. *Significant vs control (C) rats; {dagger}significant vs cold-exposed (CE) rats; {ddagger}significant vs T3-treated (HT3) rats. The level of significance was chosen as P<0.05.

 

Figure 3
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  		Fig. 3. Effect of cold exposure and hormonal [triodothyronine (T3) or thyroxine (T4)] treatment on oxidative damage of liver lipid and proteins. Hydroperoxides (A) are expressed in pmol NADP min–1 g–1 tissue; protein-bound carbonyls (B) are expressed in nmol mg–1 protein. Preparations were from control (C), 10-day cold exposed (CE), T3-treated (HT3), and T4-treated (HT4) rats. Values are means ± s.e.m. of eight different experiments. *Significant vs C rats; {dagger}significant vs CE rats; {ddagger}significant vs T3-treated (HT3) rats. The level of significance was chosen as P<0.05.

 

Figure 4
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  		Fig. 4. Effect of cold exposure and triodothyronine (T3) or thyroxine (T4) treatment on H2O2 production by succinate and pyruvate/malate-supplemented mitochondria from rat liver. Values are means ± s.e.m. of eight different experiments. *Significant vs control (C) rats; {dagger}significant vs cold-exposed (CE) rats; {ddagger}significant vs T3-treated (HT3) rats. The level of significance was chosen as P<0.05.

 

Figure 5
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  		Fig. 5. Effect of cold exposure and hormonal [triodothyronine (T3) or thyroxine (FT4)] treatment on liver response to oxidative challenge in vitro. Tissue susceptibility to stress was evaluated by determining the variations, with concentration of homogenates, of light emission from a luminescent reaction. Emission values are given a percentages of an arbitrary standard (44 ng ml–1 peroxidase). The curves were computed from experimental data using equation E=a C/exp(b C). Preparations from control (C; solid line), 10-day cold exposed (CE; dotted line), T3-treated (HT3; broken line), and T4-treated (HT4; broken line) rats.

 

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