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First published online March 8, 2005
Journal of Experimental Biology 208, 859-868 (2005)
Published by The Company of Biologists 2005
doi: 10.1242/jeb.01476
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Glucose production and substrate cycle activity in a fasting adapted animal, the northern elephant seal

Cory D. Champagne*, Dorian S. Houser and Daniel E. Crocker

Department of Biology, Sonoma State University, Rohnert Park, CA 94928, USA



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  		Fig. 1. Substrate cycles in glucose metabolism. Sites of 3H loss: 3H at C-2 of the glucose molecule is lost in the interconversion of glucose-6-phosphate (G6P) and fructose-6-phosphate (F6P); 3H at C-6 is retained through the glucose and fructose cycles and lost in the PEP and citric acid cycles. PEP, phosphoenolpyruvate; F1,6-bP, fructose-1,6 bisphosphate.

 


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  		Fig. 2. Representative clearance curves for (A) [2-3H]glucose and (B) [6-3H]glucose, and the corresponding labeled glucose structures.

 


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  		Fig. 3. The change in endogenous glucose production ({Delta}EGP) in mg glucose kg–1 min–1 over the decrease in body composition index (BCI; P=0.01). Note that the values of the x axis decrease from left to right.

 


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  		Fig. 4. The change in plasma glucose ({Delta}PG) in mg glucose dl–1 over the change in the insulin:glucagon molar ratio ({Delta}I:G; P=0.02).

 




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